Featured News

  • A research project in the laboratory investigates if protein degradation, specifically mediated by E3-ligases of the cullin family, plays important roles for muscle formation, health and function.
    In a new article, we investigated whether cullin E3-ligases are crucial for muscle differentiation. We found that blockage of cullin activity using the small molecule inhibitor MLN4924 (Pevonedistat) completely abrogates terminal muscle formation. The article was recently accepted for publication at the Journal of Molecular Biology.

Featured Work

  • We recently published a manuscript describing how the muscle specific proteins MLP and CARP are linked to chronic PKCα signaling, and contribute to the development of dilated cardiomyopathy.
    To the publication >

About the Lab

We investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. We are particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.

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