Featured Work

  • miR-486 manuscript Our new manuscript published in JCI Insight identifies a novel stretch-responsive cardiac signaling pathway involving the small micro-RNA miR-486. Our work highlights miR-486 changes in hypoplastic left heart syndrome (HLHS) and a sheep model of excessive pulmonary blood flow. Proteome data identified that this miRNA regulates Smad/FoxO1 and Stat1 signaling pathways. The full manuscript can be found here.

About the Lab

We investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. We are particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.

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Our laboratory is Green Lab Certified. We aim to do sustainable research to preserve the planets resources.

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