We recently published a manuscript describing how the muscle specific proteins MLP and CARP are linked to chronic PKCα signaling, and contribute to the development of dilated cardiomyopathy.
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A research project in the laboratory investigates if protein degradation, specifically mediated by E3-ligases of the cullin family, plays important roles for muscle formation, health and function.
In a new article, we investigated whether cullin E3-ligases are crucial for muscle differentiation. We found that blockage of cullin activity using the small molecule inhibitor MLN4924 (Pevonedistat) completely abrogates terminal muscle formation. The article was recently accepted for publication at the Journal of Molecular Biology.
About the Lab
We investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. We are particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.
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Our laboratory is Green Lab Certified. We aim to do sustainable research to preserve the planets resources.
- February 2017: New article outlining crucial functions of cullin E3-ligases for muscle formation published in the Journal of Molecular Biology.
- February 2017: Patrick presented a poster on obscurin protein functions at the Biophysics Conference in New Orleans.
- January 2017: AHA undergraduate fellowships available. More information here: AHA@UCSD.
- December 2016: Jordan presented a poster on the importance of muscle protein turnover at the ASCB meeting in San Francisco.