| Many proteins are involved in the formation and maintenance of the sarcomere, fine-tuning of its contraction and muscle specific signaling pathways. These proteins associate with at least one of the three sarcomeric filament systems through specific binding sites. Examples are the four and a half lim domain (FHL) proteins, proteins of the MARP family or obscurin family proteins. While these proteins may appear 'dispensable', mutations or loss may result in myopathies. |
| Move your mouse over the image above to see the names for some of the sarcomere-associated proteins. For more information on components of the sarcomere and their function read the review "From A to Z and back?" available online here. |